TERC and DKC1

Number of citations of the paper that reports this interaction (PubMedID 18082603)
84

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		TERC	DKC1
Description		telomerase RNA component	dyskerin pseudouridine synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Telomerase Holoenzyme Complex Cytoplasm Cajal Body Box H/ACA Telomerase RNP Complex	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex
	Molecular Function	Template For Synthesis Of G-rich Strand Of Telomere DNA Activity Telomerase Activity Telomerase RNA Reverse Transcriptase Activity RNA-directed DNA Polymerase Activity Protein Binding Protein-containing Complex Binding DNA Polymerase Binding WD40-repeat Domain Binding	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Telomere Maintenance Via Telomerase Cellular Response To Hypoxia DNA Biosynthetic Process Negative Regulation Of Cellular Senescence	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA RNA 3'-end Processing RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis
Pathways			Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Bladder cancer ( 24163127) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428) Glioma ( 28346443) Glioma (high-grade) ( 24908248) Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Multiple myeloma ( 23955597) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418) Telomere length ( 29151059 23535734 21573004 23900074 20139977 23001564) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266)
Interacting Genes		2 interacting genes: DKC1 SMN1	10 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SSR1 TERC
Entrez ID		7012	1736
HPRD ID			02129
Ensembl ID		ENSG00000277925	ENSG00000130826
Uniprot IDs			O60832
PDB IDs
Enriched GO Terms of Interacting Partners?
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