TDGF1 and ANG

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TDGF1	ANG
Description		teratocarcinoma-derived growth factor 1	angiogenin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft	Extracellular Region Basement Membrane Extracellular Space Nucleus Chromosome Nucleolus Cytosol Actin Cytoskeleton Growth Cone Cytoplasmic Vesicle Angiogenin-PRI Complex Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	DNA Binding Actin Binding Endonuclease Activity Endoribonuclease Activity Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding Protein Homodimerization Activity
	Biological Process	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone TRNA Catabolic Process Cell Migration Negative Regulation Of Translation Antibacterial Humoral Response Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Positive Regulation Of Phosphorylation Homeostatic Process Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Adherens junctions interactions tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Metabolite levels ( 23823483) Refractive error ( 32231278)	Blood protein levels ( 30072576 28240269)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8
Entrez ID		6997	283
HPRD ID		01757	00105
Ensembl ID		ENSG00000241186	ENSG00000214274
Uniprot IDs		F5H1T8 P13385	P03950 W0UV28
PDB IDs			1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V
Enriched GO Terms of Interacting Partners?
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