TCN2 and PAXIP1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		TCN2	PAXIP1
Description		transcobalamin 2	PAX interacting protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lysosomal Lumen	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Protein Binding Cobalamin Binding Metal Ion Binding	Protein Binding
	Biological Process	Cobalt Ion Transport Cobalamin Transport	Positive Regulation Of Histone H3-K36 Methylation Vasculogenesis DNA Repair DNA Recombination Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Histone Acetylation Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Response To DNA Damage Stimulus
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective TCN2 causes hereditary megaloblastic anemia Defective CD320 causes methylmalonic aciduria	Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Factor VIII levels ( 30586737) Gut microbiota relative abundance (Blautia) ( 33208821) Moyamoya disease ( 29273593) Type 2 diabetes ( 32794382) Venous thromboembolism ( 31420334) vWF levels ( 30586737)	Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: APP CBL PAXIP1 PLEKHF2 RHOU	91 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 NXT1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B
Entrez ID		6948	22976
HPRD ID		02037	08491
Ensembl ID		ENSG00000185339	ENSG00000157212
Uniprot IDs		P20062	Q6ZW49
PDB IDs		2BB5 4ZRP 4ZRQ 5NO0 5NP4 5NRP 5NSA	3SQD
Enriched GO Terms of Interacting Partners?
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