MLX and TNNT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MLX	TNNT2
Description		MAX dimerization protein MLX	troponin T2, cardiac type
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Protein-macromolecule Adaptor Activity Troponin I Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Regulation Of Muscle Filament Sliding Speed Sarcomere Organization Response To Calcium Ion Actin Crosslink Formation Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression	Striated Muscle Contraction
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Type 2 diabetes ( 30297969 29632382 30718926) Type 2 diabetes (time to event) ( 32589924) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)
Interacting Genes		31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620	16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69
Entrez ID		6945	7139
HPRD ID		04278	01844
Ensembl ID		ENSG00000108788	ENSG00000118194
Uniprot IDs		Q9UH92	A0A0A0MRJ5 P45379 Q15607
PDB IDs			1J1D 1J1E 4Y99 6KN7 6KN8
Enriched GO Terms of Interacting Partners?
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