TBX15 and DOK6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TBX15	DOK6
Description		T-box transcription factor 15	docking protein 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin RNA Polymerase II Transcription Repressor Complex	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade
Pathways			RET signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Antitragus size ( 26105758) Birth weight ( 31043758) Body mass index ( 28892062 25673413) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) Chin dimples ( 27182965) Congenital heart malformation ( 23708190) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Ear morphology ( 26105758) Excessive hairiness ( 29895819) Facial morphology ( 31763980) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Folding of antihelix ( 26105758) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung function (FVC) ( 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Major depressive disorder x sex interaction ( 34099189) Male-pattern baldness ( 27182965 28196072) Physiological traits ( 31902109) Recurrent major depressive disorder ( 34099189) Recurrent major depressive disorder x sex interaction ( 34099189) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412 28448500)	Bone fracture in osteoporosis ( 28580392) Caudate activity during reward ( 28927378) Mean platelet volume ( 31194788) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Osteoporosis-related phenotypes ( 20548944) Platelet distribution width ( 32888494) Pursuit maintenance gain ( 29064472) Response to cytidine analogues (gemcitabine) ( 24483146) Skin aging (microtopography measurement) ( 28502801)
Interacting Genes		12 interacting genes: ATXN1 DOK6 DTX2 HOXA1 MYOZ3 NTAQ1 POLE2 RHOBTB3 TBX6 TEKT5 VENTX VGLL3	21 interacting genes: ABHD11 ARID5A C1orf94 CD226 CRYBB3 EGFR ERBB2 FAM86C1P LASP1 LGALS14 METTL27 NTRK3 PRR22 RBPMS RET RUSC1 SLC30A6 TBX15 TLE5 USP54 YPEL3
Entrez ID		6913	220164
HPRD ID		16035	13244
Ensembl ID		ENSG00000092607	ENSG00000206052
Uniprot IDs		Q8N8P2 Q96SF7	Q6PKX4
PDB IDs
Enriched GO Terms of Interacting Partners?
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