TAP1 and TDP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TAP1	TDP2
Description		transporter 1, ATP binding cassette subfamily B member	tyrosyl-DNA phosphodiesterase 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body
	Molecular Function	Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity ADP Binding Metal Ion Binding TAP1 Binding TAP2 Binding Peptide Transmembrane Transporter Activity	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Transmembrane Transport	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)	Colorectal or endometrial cancer ( 26621817)
Interacting Genes		27 interacting genes: AQP6 CHRM3 CREB3 ERGIC3 ERVFRD-1 ESR1 GEMIN4 GPR152 HLA-F HLA-G KRTAP4-12 LCE2C LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 RNF19B SLC10A1 SLC10A6 SLC35C2 SSMEM1 TAP2 TAPBP TDP2 TMEM14B	37 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 NOTCH4 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1
Entrez ID		6890	51567
HPRD ID		01359	05771
Ensembl ID		ENSG00000168394	ENSG00000111802
Uniprot IDs		A0A0S2Z5A6 B7Z7P4 Q03518 X5CKB3	A0A384MDM5 O95551
PDB IDs		1JJ7 5U1D	5INO 5J3P 5J3S 6Q00 6Q01
Enriched GO Terms of Interacting Partners?
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