SYT1 and GIMAP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SYT1	GIMAP5
Description		synaptotagmin 1	GTPase, IMAP family member 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Synaptic Vesicle Integral Component Of Synaptic Vesicle Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Neuron Projection Terminus Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Lysosomal Membrane Integral Component Of Membrane Multivesicular Body Membrane
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Syntaxin Binding Clathrin Binding Syntaxin-3 Binding Identical Protein Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding Calcium Ion Sensor Activity	Protein Binding GTP Binding
	Biological Process	Detection Of Calcium Ion Chemical Synaptic Transmission Neurotransmitter Secretion Brain Development Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Positive Regulation Of Dopamine Secretion Vesicle Docking Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Protein Heterooligomerization Regulation Of Synaptic Transmission, Glutamatergic Spontaneous Neurotransmitter Secretion Cellular Response To Calcium Ion Synchronous Neurotransmitter Secretion Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway Positive Regulation Of Dendrite Extension
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type G (botG) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Adiponectin levels ( 33562295) Brain morphology (MOSTest) ( 32665545) Chloride levels ( 29403010) Estimated glomerular filtration rate ( 31217584) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Intelligence (MTAG) ( 29326435) Lung function ( 31902109) Lysophosphatidylcholine levels ( 31551469) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) QRS duration ( 31251759) Sodium levels ( 29403010) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653)
Interacting Genes		46 interacting genes: BNIP2 BTN2A2 CACNA1A CACNB3 CACNB4 CALM1 CREBBP CSGALNACT2 CYB5B DANCR FGF1 GIMAP5 GOLM1 HMOX2 IKBKG IRF3 MIP NAPB NEDD4 NR1H3 NR3C1 NRXN1 PPARG RACK1 RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A TMEM14C TMEM254 TMEM60 TSHR UBIAD1 ZDHHC17 ZFPL1	65 interacting genes: ADGRG3 APP AQP3 AQP6 ARL13B BTNL9 CD33 CD53 CHPF2 CLDN7 CREB3L1 CYB561 CYBRD1 DKK4 EBP EDA EDA2R ELOVL4 EMP1 ERGIC3 EVI2B FAM174A FAM210B FATE1 FCER1G GJA8 GJB3 GORAB GRAMD2B IFNGR2 JAGN1 KASH5 KIR3DL3 LAYN LDLRAD1 LSMEM2 M6PR MGST2 MGST3 MILR1 MS4A14 PDZK1IP1 PTGES RETREG3 RNASEK RNF19B SCN3B SHISAL1 SLC10A1 SLC35C2 SMIM3 SPACA1 STOM STX1A STX2 STX4 SYT1 TM4SF18 TM4SF19 TMEM31 TMX1 TMX2 TNFRSF19 TSPAN18 ZFYVE27
Entrez ID		6857	55340
HPRD ID		01710	16280
Ensembl ID		ENSG00000067715	ENSG00000196329
Uniprot IDs		A0A024RBE9 J3KQA0 P21579	A0A090N8P9 Q96F15
PDB IDs		2K45 2K4A 2K8M 2KI6 2LHA 2N1T 2R83 3F00 3F01 3F04 3F05 4ISQ 4V11 6G5F 6G5K 6QNS 6TZ3 6U41 6U4U 6U4W 6ZVN
Enriched GO Terms of Interacting Partners?
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