SYN2 and SYN1

Number of citations of the paper that reports this interaction (PubMedID 10358015)
31

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SYN2	SYN1
Description		synapsin II	synapsin I
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Synaptic Vesicle Membrane SNARE Complex Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Synaptonemal Complex Golgi Apparatus Cytosol Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Extrinsic Component Of Synaptic Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	ATP Binding Identical Protein Binding	Actin Binding Transporter Activity ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding
	Biological Process	Chemical Synaptic Transmission Neurotransmitter Secretion Calcium-ion Regulated Exocytosis Synaptic Vesicle Clustering	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Sensory processing of sound by inner hair cells of the cochlea
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS		Body shape index ( 34021172) Chronic obstructive pulmonary disease ( 30804561) Circulating leptin levels or type 2 diabetes ( 32341051) Creatinine levels ( 29403010) Eosinophil counts ( 32888494) Estimated glomerular filtration rate ( 31152163) Fasting blood insulin (BMI interaction) ( 22581228) Glomerular filtration rate ( 29403010) Glycated hemoglobin levels ( 34059833 28898252) Heel bone mineral density ( 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Leprosy ( 27976721) Nontraumatic osteonecrosis of the femoral head ( 32701715) Platelet count ( 22139419 29403010) Thyroid stimulating hormone levels ( 32769997 25743335) Triglycerides ( 30275531) Type 2 diabetes ( 18372903) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: CHRM4 NOS1AP PRKACA SYN1 SYN3 YWHAE YWHAZ	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		6854	6853
HPRD ID		02857	02433
Ensembl ID		ENSG00000157152	ENSG00000008056
Uniprot IDs		B3KRB3 Q59GM1 Q86VA8 Q92777	P17600
PDB IDs
Enriched GO Terms of Interacting Partners?
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