SUPT5H and IK

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		SUPT5H	IK
Description		SPT5 homolog, DSIF elongation factor subunit	IK cytokine
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Macroautophagy Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Polyadenylation	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Mitotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) White blood cell count ( 32888494)	Monocyte count ( 32888494) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		45 interacting genes: C9orf78 CCNH CCNT1 CCNT2 CDK7 CDK9 CEP55 CSNK2A1 DBN1 DCAF6 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 SAP30BP SIK1 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 ZBTB3 ZFYVE9 ZNF496 ZNF512B	27 interacting genes: APP CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 FXR1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 OGT PFN2 QARS1 RACK1 RBM10 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10
Entrez ID		6829	3550
HPRD ID		03655	02771
Ensembl ID		ENSG00000196235	ENSG00000113141
Uniprot IDs		O00267	Q13123 Q95HA6 Q9UK43
PDB IDs		2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED	5O9Z 6Q8I
Enriched GO Terms of Interacting Partners?
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