STAT5A and TSLP

Number of citations of the paper that reports this interaction (PubMedID 11418668)
137

Data Source:
HPRD (in vivo)

		STAT5A	TSLP
Description		signal transducer and activator of transcription 5A	thymic stromal lymphopoietin
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol	Extracellular Region Extracellular Space
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Cytokine Activity Interleukin-7 Receptor Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Lactation Cytokine-mediated Signaling Pathway Taurine Metabolic Process Reelin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Hormone Receptor Signaling Pathway Via JAK-STAT	Positive Regulation Of Cytokine-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Chemokine (C-C Motif) Ligand 1 Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Prolactin receptor signaling Nuclear signaling by ERBB4 Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Inactivation of CSF3 (G-CSF) signaling Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling Growth hormone receptor signaling	Interleukin-7 signaling Interleukin-7 signaling
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 27569725 28067908 23128233) Low density lipoprotein cholesterol levels ( 32154731) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 22036096) Allergic sensitization ( 23817571) Asthma ( 21804548 21804549 31361310 31959851 30929738 34103634 27611488 27182965 32296059 31619474 29785011 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eosinophil counts ( 19198610 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25017104 25407941) Eosinophilic granulomatosis with polyangiitis ( 31719529) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Self-reported allergy ( 23817569)
Interacting Genes		72 interacting genes: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FBXW7 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK MAGEA12 MAPK1 MAPK3 MRPS6 NCOR2 NMI NR3C1 OLIG1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TET2 TSLP TXNDC11 UGT2B4 WASH2P ZNF596	8 interacting genes: APP CRLF2 FBXO7 IKBKG IL7R PRNP STAT3 STAT5A
Entrez ID		6776	85480
HPRD ID		03301	06108
Ensembl ID		ENSG00000126561	ENSG00000145777
Uniprot IDs		A0A384N5W4 A0A7I2YQF1 A8K6I5 K7EK35 P42229 Q59GY7	Q969D9
PDB IDs			5J11 5J12 5J13
Enriched GO Terms of Interacting Partners?
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