STAT2 and IFNAR2

Number of citations of the paper that reports this interaction (PubMedID 9121453)
49

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology)
HPRD (in vitro, in vivo)

		STAT2	IFNAR2
Description		signal transducer and activator of transcription 2	interferon alpha and beta receptor subunit 2
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mitochondrial Fission	Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Response To Interferon-beta Defense Response To Virus Type I Interferon Signaling Pathway
Pathways		Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Human interferon omega-1 Nylidrin
Diseases
GWAS		Axial length ( 24144296) Height ( 20881960 25429064 23456168) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Psoriasis ( 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)	Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) Crohn's disease ( 23128233) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Type 2 diabetes ( 30130595)
Interacting Genes		22 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA GSK3A GSK3B HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2	15 interacting genes: HLCS IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		6773	3455
HPRD ID		02778	03850
Ensembl ID		ENSG00000170581	ENSG00000159110
Uniprot IDs		P52630 R9QE65	P48551 Q9BUA0
PDB IDs		2KA4 6UX2 6WCZ	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?
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