SPI1 and MECP2

Number of citations of the paper that reports this interaction (PubMedID 16331260)
47

Data Source:
BioGRID (pull down)

		SPI1	MECP2
Description		Spi-1 proto-oncogene	methyl-CpG binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Heterochromatin Extracellular Space Nucleus Nucleoplasm Centrosome Cytosol Postsynapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Histone Deacetylase Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding STAT Family Protein Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Protein N-terminus Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Germinal Center B Cell Differentiation Follicular B Cell Differentiation Immature B Cell Differentiation Defense Response To Tumor Cell Pro-T Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Somatic Stem Cell Population Maintenance TRAIL-activated Apoptotic Signaling Pathway Myeloid Dendritic Cell Differentiation Negative Regulation Of Neutrophil Degranulation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-binding Transcription Factor Activity Anatomical Structure Regression Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Histone H4 Acetylation Oncogene-induced Cell Senescence Endothelial To Hematopoietic Transition Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of P38MAPK Cascade Negative Regulation Of NIK/NF-kappaB Signaling Regulation Of Histone H3-K27 Acetylation Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Microglial Cell Mediated Cytotoxicity Negative Regulation Of Adipose Tissue Development Pericyte Cell Differentiation Positive Regulation Of Antifungal Innate Immune Response Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Myeloid Dendritic Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Glutamine Metabolic Process Cellular Biogenic Amine Metabolic Process Mitotic Spindle Organization Synapse Assembly Respiratory Gaseous Exchange By Respiratory System Long-term Memory Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Visual Learning Post-embryonic Development Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Dendrite Development Negative Regulation Of Angiogenesis Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Cardiolipin Metabolic Process Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Positive Regulation Of Microtubule Nucleation Positive Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of DNA Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Hematocrit ( 32888494) Hematology traits ( 30576415) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 25173106) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean platelet volume ( 32888494) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278)	Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 26663301 26502338 19838195)
Interacting Genes		47 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FBXW7 FOS FUS GATA1 GATA2 GATA3 GFI1 GSK3B HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1	20 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HDAC1 HIPK2 HMGB1 LBR NCOR1 PRKACA PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1
Entrez ID		6688	4204
HPRD ID		01305	02050
Ensembl ID		ENSG00000066336	ENSG00000169057
Uniprot IDs		P17947	A0A140VKC4 D3YJ43 P51608 Q59FJ6
PDB IDs			1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK
Enriched GO Terms of Interacting Partners?
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