SPARC and TGM2

Number of citations of the paper that reports this interaction (PubMedID 7730416)
30

Data Source:
HPRD (in vitro)

		SPARC	TGM2
Description		secreted protein acidic and cysteine rich	transglutaminase 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Endocytic Vesicle Lumen Glutamatergic Synapse	Chromatin Nucleus Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Extracellular Matrix Intrinsic Component Of Plasma Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Extracellular Matrix Binding	Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Protein Domain Specific Binding Identical Protein Binding Protein-glutamine Glutaminase Activity Histone Serotonyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity
	Biological Process	Ossification Negative Regulation Of Endothelial Cell Proliferation Heart Development Response To Gravity Response To Lead Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Lung Development Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Cytokine Wound Healing Response To Peptide Hormone Response To Ethanol Response To Cadmium Ion Inner Ear Development Anatomical Structure Development Regulation Of Synapse Organization Response To Glucocorticoid Response To CAMP Response To Calcium Ion	Blood Vessel Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance
Pathways		Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Guanosine-5'-Diphosphate Hexylresorcinol
Diseases
GWAS		Stroke ( 32693751)
Interacting Genes		24 interacting genes: COL13A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HDAC5 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 TNC UBQLN1 VEGFA XRCC6 ZNF579	60 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 MMP14 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		6678	7052
HPRD ID		01631	01825
Ensembl ID		ENSG00000113140	ENSG00000198959
Uniprot IDs		P09486	B4DIT7 B4DTN7 P21980 V9HWG3
PDB IDs		1BMO 1NUB 1SRA 2V53	1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB
Enriched GO Terms of Interacting Partners?
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