SOX10 and PRRX2

Number of citations of the paper that reports this interaction (PubMedID 16582099)
62

Data Source:
HPRD (two hybrid)

		SOX10	PRRX2
Description		SRY-box transcription factor 10	paired related homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Extrinsic Component Of Mitochondrial Outer Membrane	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Melanocyte Differentiation Positive Regulation Of Myelination Lacrimal Gland Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Cellular Response To Xenobiotic Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494)	Response to exercise (triglyceride level interaction) ( 26491034)
Interacting Genes		36 interacting genes: ALX4 C10orf55 CDK6 CEBPA CRX DAZAP2 DLX5 EGR2 EXOC5 GSK3B HHEX HIVEP1 HOXA3 HOXC4 HSF4 JUN MAGED1 MAPK1 MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 POU6F2 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1	3 interacting genes: CASP8 NUP214 SOX10
Entrez ID		6663	51450
HPRD ID		03752	05244
Ensembl ID		ENSG00000100146	ENSG00000167157
Uniprot IDs		A0A024R1N6 P56693	A0A140VJS2 Q99811
PDB IDs
Enriched GO Terms of Interacting Partners?
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