SOD1 and BCL2

Number of citations of the paper that reports this interaction (PubMedID 15233914)
151

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		SOD1	BCL2
Description		superoxide dismutase 1	BCL2 apoptosis regulator
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosome Peroxisome Cytosol Plasma Membrane Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Protein-containing Complex Neuronal Cell Body Extracellular Exosome Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Membrane Protein-containing Complex Myelin Sheath Pore Complex
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Protein Phosphatase 2B Binding Small GTPase Binding Identical Protein Binding Chaperone Binding	Protease Binding Protein Binding Channel Activity Channel Inhibitor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity BH3 Domain Binding Protein Phosphatase 2A Binding DNA-binding Transcription Factor Binding
	Biological Process	Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Glutathione Metabolic Process Superoxide Metabolic Process Cellular Iron Ion Homeostasis Spermatogenesis Embryo Implantation Cell Aging Sensory Perception Of Sound Locomotory Behavior Anterograde Axonal Transport Retrograde Axonal Transport Regulation Of Blood Pressure Response To Heat Response To Xenobiotic Stimulus Response To Organic Substance Transmission Of Nerve Impulse Removal Of Superoxide Radicals Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Protein Kinase Activity Regulation Of Organ Growth Response To Antibiotic Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Regulation Of Mitochondrial Membrane Potential Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Associated Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Protein Polyubiquitination Ossification Ovarian Follicle Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Behavioral Fear Response B Cell Homeostasis Release Of Cytochrome C From Mitochondria Regulation Of Cell-matrix Adhesion Lymphoid Progenitor Cell Differentiation B Cell Lineage Commitment Response To Ischemia Renal System Process Protein Dephosphorylation Melanin Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Humoral Immune Response Cellular Response To DNA Damage Stimulus Actin Filament Organization Axonogenesis Female Pregnancy Cell Aging Positive Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Radiation Response To Xenobiotic Stimulus Response To Toxic Substance Post-embryonic Development Response To Iron Ion Response To UV-B Response To Gamma Radiation Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Glycoprotein Biosynthetic Process Mesenchymal Cell Development Positive Regulation Of Neuron Maturation Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cochlear Nucleus Development Gland Morphogenesis Regulation Of Transmembrane Transporter Activity Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Melanocyte Differentiation Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Hair Follicle Morphogenesis Axon Regeneration Regulation Of Protein Stability Endoplasmic Reticulum Calcium Ion Homeostasis Glomerulus Development Negative Regulation Of Cellular PH Reduction Regulation Of Protein Localization Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Osteoblast Proliferation Response To Cytokine Response To Nicotine Organ Growth Positive Regulation Of Multicellular Organism Growth B Cell Proliferation Cellular Response To Glucose Starvation Response To Hydrogen Peroxide T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Neuron Apoptotic Process Ear Development Regulation Of Viral Genome Replication Positive Regulation Of Melanocyte Differentiation Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Focal Adhesion Assembly Spleen Development Thymus Development Digestive Tract Morphogenesis Oocyte Development Positive Regulation Of Skeletal Muscle Fiber Development Pigment Granule Organization Homeostasis Of Number Of Cells Within A Tissue B Cell Receptor Signaling Pathway Response To Glucocorticoid Neuron Apoptotic Process Defense Response To Virus Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Depolarization Regulation Of Calcium Ion Transport Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Organic Substance Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		Dopamine Isoprenaline Zinc 5-fluorouridine S-oxy-L-cysteine Arimoclomol Cannabidiol Medical Cannabis Nabiximols Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Ibuprofen Paclitaxel Docetaxel Rasagiline Paclitaxel docosahexaenoic acid Apoptone Glycine betaine Eribulin Dexibuprofen Isosorbide Venetoclax Obatoclax Navitoclax
Diseases
GWAS		Amyotrophic lateral sclerosis ( 20801718)	Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301 34315874) Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Body mass index ( 28892062 25673413) Body mass index and fasting insulin (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Cardiac Troponin-T levels ( 23247143) Chronic lymphocytic leukemia ( 28165464 26956414 23770605) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Excessive hairiness ( 29895819) Fasting insulin ( 34059833) Follicular lymphoma ( 25279986) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Red blood cell count ( 32888494 27863252) Response to adalimumab in hidradenitis suppurativa (abscess and inflammatory nodule count increase) ( 31465739) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum total protein level ( 29403010) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Two-hour glucose ( 34059833) Type 2 diabetes ( 28869590) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		17 interacting genes: AMFR BCL2 CCS COMMD1 CRYAB DNAH3 DNAJB1 HLCS HOXB2 KARS1 MARCHF5 MYCBP2 PARK7 PPP3CA RNF19A SMAD2 UBE3A	87 interacting genes: ATP2A2 BAD BAG1 BAG3 BAG4 BAK1 BAX BBC3 BCAP31 BCL2L1 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BFAR BID BIK BLK BMF BNIP1 BNIP2 BNIP3 BNIP3L BNIPL CAPN2 CASP3 CASP8 CDK1 CDK2 CPT1A CYCS FKBP8 HNRNPD HRAS HRK HSPA1A ITM2B ITPR1 KRAS MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MEX3D MOAP1 MYC NLRP1 NMT2 NR4A1 NRAS PARP1 PIN1 PKMYT1 PMAIP1 PML PPARA PPID PPP1CA PPP2CA PPP2R5A PPP3CA PPP3CC PRKACA PRKCA PSEN1 PXN RAD9A RAF1 RNF183 RRAS RTN4 SEPTIN4 SF1 SMN1 SOD1 SPHK2 SPNS1 SQSTM1 TMBIM6 TOMM20 TP53 TP53AIP1 TP53BP2 XIAP
Entrez ID		6647	596
HPRD ID		00937	01045
Ensembl ID		ENSG00000142168	ENSG00000171791
Uniprot IDs		P00441 V9HWC9	A0A024R2B3 A0A024R2C4 A0A7I2V3S7 P10415
PDB IDs		1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4MCM 4MCN 4NIN 4NIO 4NIP 4OH2 4SOD 4XCR 5DLI 5IIW 5J07 5J0C 5J0F 5J0G 5K02 5O3Y 5O40 5U9M 5WMJ 5WOR 5YTO 5YTU 5YUL 6A9O 6B79 6DTK 6FFK 6FLH 6FOI 6FOL 6FON 6FP6 6SPA 6SPH 6SPI 6SPJ 6SPK 6Z3V 6Z4G 6Z4H 6Z4I 6Z4J 6Z4K 6Z4L 6Z4M 6Z4O	1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4MAN 5AGW 5AGX 5FCG 5JSN 5VAU 5VAX 5VAY 6GL8 6IWB 6O0K 6O0L 6O0M 6O0O 6O0P
Enriched GO Terms of Interacting Partners?
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