SNCG and GRK5

Number of citations of the paper that reports this interaction (PubMedID 10852916)
132

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		SNCG	GRK5
Description		synuclein gamma	G protein-coupled receptor kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Spindle Neuronal Cell Body Axon Terminus Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	Protein Binding Cuprous Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Chemical Synaptic Transmission Adult Locomotory Behavior Protein Secretion Regulation Of Dopamine Secretion Regulation Of Neurotransmitter Secretion Synaptic Vesicle Endocytosis Synapse Organization Regulation Of Neuron Death	Protein Phosphorylation Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Cell Cycle
Pathways			G alpha (q) signalling events G alpha (s) signalling events
Drugs
Diseases
GWAS			Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31420334 31676865) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		12 interacting genes: ADRB2 BUB1B GRK1 GRK5 GRK6 MAPK1 MAPK3 MAPK8 PCBP1 POT1 TERF1 TERF2IP	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		6623	2869
HPRD ID		04297	02926
Ensembl ID		ENSG00000173267	ENSG00000198873
Uniprot IDs		F8W754 O76070 Q6FHG5	P34947
PDB IDs			4TNB 4TND 6PJX
Enriched GO Terms of Interacting Partners?
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