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SNCA and UBE2W
Number of citations of the paper that reports this interaction (PubMedID
31518613
)
10
Data Source:
BioGRID
(enzymatic study)
SNCA
UBE2W
Description
synuclein alpha
ubiquitin conjugating enzyme E2 W
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nuclear Outer Membrane
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Mitochondrial Matrix
Lysosome
Rough Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Ribosome
Plasma Membrane
Cell Cortex
Actin Cytoskeleton
Membrane
Inclusion Body
Axon
Growth Cone
Synaptic Vesicle Membrane
Platelet Alpha Granule Membrane
Protein-containing Complex
Neuronal Cell Body
Terminal Bouton
Axon Terminus
Perinuclear Region Of Cytoplasm
Postsynapse
Supramolecular Fiber
Nucleus
Nucleoplasm
Molecular Function
SNARE Binding
Magnesium Ion Binding
Transcription Cis-regulatory Region Binding
Actin Binding
Protein Kinase Inhibitor Activity
Fatty Acid Binding
Copper Ion Binding
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Microtubule Binding
Ferrous Iron Binding
Zinc Ion Binding
Oxidoreductase Activity
Kinesin Binding
Protein Domain Specific Binding
Hsp70 Protein Binding
Histone Binding
Identical Protein Binding
Alpha-tubulin Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Phospholipase Binding
Protein N-terminus Binding
Tau Protein Binding
Beta-tubulin Binding
Phosphoprotein Binding
Phospholipase D Inhibitor Activity
Dynein Complex Binding
Cuprous Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Positive Regulation Of Receptor Recycling
Positive Regulation Of Neurotransmitter Secretion
Negative Regulation Of Protein Kinase Activity
Fatty Acid Metabolic Process
Neutral Lipid Metabolic Process
Phospholipid Metabolic Process
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Mitochondrial Membrane Organization
Chemical Synaptic Transmission
Aging
Adult Locomotory Behavior
Response To Xenobiotic Stimulus
Response To Iron(II) Ion
Regulation Of Phospholipase Activity
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Glutamate Secretion
Regulation Of Dopamine Secretion
Synaptic Vesicle Exocytosis
Synaptic Vesicle Priming
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Microtubule Polymerization
Receptor Internalization
Protein Destabilization
Response To Magnesium Ion
Negative Regulation Of Transporter Activity
Response To Lipopolysaccharide
Negative Regulation Of Monooxygenase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Interferon-gamma
Cellular Response To Oxidative Stress
Negative Regulation Of Histone Acetylation
SNARE Complex Assembly
Positive Regulation Of SNARE Complex Assembly
Regulation Of Locomotion
Dopamine Biosynthetic Process
Mitochondrial ATP Synthesis Coupled Electron Transport
Regulation Of Macrophage Activation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Endocytosis
Negative Regulation Of Exocytosis
Positive Regulation Of Exocytosis
Negative Regulation Of Dopamine Metabolic Process
Behavioral Response To Cocaine
Regulation Of Long-term Neuronal Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Positive Regulation Of Inflammatory Response
Synapse Organization
Regulation Of Acyl-CoA Biosynthetic Process
Protein Tetramerization
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Serotonin Uptake
Regulation Of Norepinephrine Uptake
Negative Regulation Of Norepinephrine Uptake
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Response To Interleukin-1
Cellular Response To Copper Ion
Cellular Response To Epinephrine Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Supramolecular Fiber Organization
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Neuron Death
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Positive Regulation Of Glutathione Peroxidase Activity
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Regulation Of Synaptic Vesicle Recycling
Regulation Of Reactive Oxygen Species Biosynthetic Process
Response To Desipramine
Negative Regulation Of Chaperone-mediated Autophagy
Regulation Of Presynapse Assembly
Protein Polyubiquitination
DNA Repair
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Response To Misfolded Protein
Pathways
Amyloid fiber formation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Resveratrol
Copper
Diseases
GWAS
Anxiety (
33859377
)
Blood protein levels (
30072576
29875488
)
Dementia with Lewy bodies (
29263008
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Feeling nervous (
29500382
)
Neurociticism (
29500382
)
Parkinson's disease (
22451204
20711177
21084426
21292315
19915575
19915576
25064009
32201043
31660654
27182965
28892059
22438815
28011712
20070850
21044948
24511991
21738487
32310270
)
Parkinson's disease (age of onset) (
31660654
33884653
30957308
)
Parkinson's disease in GBA mutation carriers (
31755958
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Response to bupropion in depression (
27622933
)
Cervical high-risk human papilloma virus infection (
33225922
)
Malaria (
31844061
)
Manganese levels (
26025379
)
Urate levels in obese individuals (
25811787
)
Interacting Genes
128 interacting genes:
A1BG
ACTA1
ADAP2
ADRB2
AKT1
AMBRA1
ANXA6
APLP1
APOE
APP
ARHGAP15
ARPP19
ARSA
BAD
BAG5
BCL2L1
BDH2
CALM1
CAV1
CDC42EP2
CDC42EP3
CDC42SE1
CDK4
CHRM5
COL25A1
CRYAB
CSNK1A1
CSNK1D
CSNK2A1
CSNK2A2
CTNND1
CTSD
CYCS
DMTN
DNAJC5
DOCK7
DYRK1A
EEF1A1
EGFR
EIF3G
ELK1
ENC1
ENSA
FBXL5
FGR
FKBP4
FYN
GABARAPL1
GAPDH
GBA
GRK1
GRK2
GRK5
GRK6
GSK3B
H1-1
H1-2
HSD17B4
HSP90AA1
HSPB2
HSPB6
HSPB8
KIAA1191
KLC1
KLK6
LYN
MAP1B
MAPK1
MAPK8IP1
MAPT
MEF2D
MT-CO1
MT-CO3
NEDD4
NEDD4L
PAK3
PARK7
PDE4DIP
PDIA2
PELP1
PFDN2
PLCB2
PLD1
PLK1
PLK2
PLK3
PPP3CA
PRDX1
PREP
PRKCE
PRKN
PTK2B
RABAC1
RNF10
SAP30BP
SDF4
SEPTIN4
SIAH2
SLC6A3
SMURF2
SNCAIP
SNCB
SPTBN1
SQSTM1
SRC
SRI
STAMBP
SYK
SYN1
TGM1
TH
TOMM20
TOR1A
TPPP
TUBA1A
UBB
UBC
UBE2D2
UBE2W
USP2
USP47
USP7
USP8
YOD1
YWHAB
YWHAE
YWHAH
ZRANB1
80 interacting genes:
AKR1C3
AMFR
ATXN3
BARD1
BFAR
BIRC2
BIRC8
BRCA1
CADPS2
CBL
CHFR
CNOT4
DNMT3B
DTX3
DTX3L
DZIP3
EED
ELOC
FANCL
LRSAM1
MAP3K1
MAPT
MARCHF3
MARCHF5
MGRN1
MIB1
MID1
MKRN1
MKRN3
MUL1
PJA2
POLR2C
PSTPIP1
RFWD3
RMND5B
RNF10
RNF103
RNF111
RNF114
RNF115
RNF123
RNF125
RNF138
RNF14
RNF150
RNF152
RNF165
RNF166
RNF167
RNF183
RNF185
RNF2
RNF26
RNF31
RNF4
RNF5
RNF8
ROPN1
SNCA
STUB1
TOPORS
TRIM17
TRIM2
TRIM23
TRIM27
TRIM31
TRIM35
TRIM39
TRIM5
TRIM59
TRIM8
UBA1
UBOX5
UFM1
UHRF2
USHBP1
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
6622
55284
HPRD ID
01227
07724
Ensembl ID
ENSG00000145335
ENSG00000104343
Uniprot IDs
H6UYS5
P37840
Q96B02
Q96FI0
X6REH9
PDB IDs
1XQ8
2JN5
2KKW
2M55
2N0A
2X6M
3Q25
3Q26
3Q27
3Q28
3Q29
4BXL
4R0U
4R0W
4RIK
4RIL
4ZNN
5CRW
6A6B
6CT7
6CU7
6CU8
6FLT
6H6B
6I42
6L1T
6L1U
6L4S
6LRQ
6OSJ
6OSL
6OSM
6PEO
6PES
6RT0
6RTB
6SST
6SSX
6UFR
6XYO
6XYP
6XYQ
7NCA
7NCG
7NCH
7NCI
7NCJ
7NCK
2A7L
2MT6
Enriched GO Terms of Interacting Partners
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