SUMO3 and SENP5

Number of citations of the paper that reports this interaction (PubMedID 16608850)
93

Data Source:
BioGRID (enzymatic study)

		SUMO3	SENP5
Description		small ubiquitin like modifier 3	SUMO specific peptidase 5
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body	Nucleus Nucleoplasm Nucleolus Centrosome Cytosol
	Molecular Function	Protein Binding Protein Tag Ubiquitin-like Protein Ligase Binding	Protein Binding SUMO-specific Protease Activity SUMO-specific Endopeptidase Activity
	Biological Process	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus	Cell Cycle Protein Desumoylation Cell Division
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	SUMO is proteolytically processed
Drugs
Diseases
GWAS		Delirium ( 29631748)	Gestational age at birth (child effect) ( 31194736) Malaria ( 31844061) Night sleep phenotypes ( 27126917)
Interacting Genes		55 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FAM221A FOS HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TRAPPC10 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZNF496	3 interacting genes: RABGAP1 SUMO2 SUMO3
Entrez ID		6612	205564
HPRD ID		03754	10222
Ensembl ID		ENSG00000184900	ENSG00000119231
Uniprot IDs		P55854	B2R9F5 Q96HI0
PDB IDs		1U4A 2IO1 2MP2 6K5R 6NNQ
Enriched GO Terms of Interacting Partners?
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