LRRC61 and IRF5

		LRRC61	IRF5
Description		leucine rich repeat containing 61	interferon regulatory factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Immune System Process Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus
Pathways			Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678)	Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diffuse cutaneous systemic sclerosis ( 29293537) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (alkaline phosphatase) ( 33972514) Primary biliary cholangitis ( 21399635 20639880 26394269) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 21156761 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) SjÃ¶gren's syndrome ( 24097067 28076899) Systemic lupus erythematosus ( 27399966 18204446 24871463 26606652 23273568 33272962 26663301 23053960 26502338 18204098 21408207 32771030 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 21750679 31672989 30572963 20383147 30247649 29293537 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 28067908 26398853 23128233 21297633)
Interacting Genes		8 interacting genes: C1orf216 EFHC1 ENKD1 FAM222B HGS IRF5 PKN1 TRIP13	21 interacting genes: ALPI COPS3 CPA2 CREBBP EP300 HDAC1 IKBKE IRF3 LRRC61 MAVS MEST MYD88 NCOR2 NDUFA5 SGTA SIN3A TBK1 TRAF6 TRIM15 TRIM21 XPO1
Entrez ID		65999	3663
HPRD ID		08326	06240
Ensembl ID		ENSG00000127399	ENSG00000128604
Uniprot IDs		A0A090N7W5 Q9BV99	A0A0G2USB5 B7Z1M2 C9JAU6 Q13568
PDB IDs			3DSH
Enriched GO Terms of Interacting Partners?
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