HLTF and SP3

Number of citations of the paper that reports this interaction (PubMedID 10391891)
15

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HLTF	SP3
Description		helicase like transcription factor	Sp3 transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane	Chromatin Nucleus Nucleoplasm PML Body Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity ATP-dependent Chromatin Remodeler Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	SUMOylation of transcription factors
Drugs
Diseases
GWAS			End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745 29874175) Sensation seeking ( 30718321)
Interacting Genes		13 interacting genes: CDK9 DCAF1 EEF1G EWSR1 HSPA8 SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4	30 interacting genes: AKT1 CIB3 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF LIN54 NKX3-1 PAK6 PHF21A PIAS1 POGZ RB1 RBBP4 RPS20 SNRPB SP1 SPANXN2 STK19 SUMO1 TP53 TP73 UBE2I VEGFA ZBTB7A
Entrez ID		6596	6670
HPRD ID		04461	03483
Ensembl ID		ENSG00000071794	ENSG00000172845
Uniprot IDs		A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527	B7ZLN9 Q02447 Q59FX5 Q86TP0
PDB IDs		2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F 6KCS
Enriched GO Terms of Interacting Partners?
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