SLC12A1 and OXSR1

Number of citations of the paper that reports this interaction (PubMedID 12386165)
156

Data Source:
HPRD (two hybrid)

		SLC12A1	OXSR1
Description		solute carrier family 12 member 1	oxidative stress responsive kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome	Cytosol Extracellular Exosome
	Molecular Function	Sodium:potassium:chloride Symporter Activity Potassium:chloride Symporter Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Ion Transport Cell Volume Homeostasis Ion Transmembrane Transport Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Protein Phosphorylation Response To Oxidative Stress Signal Transduction Osmosensory Signaling Pathway Positive Regulation Of T Cell Chemotaxis Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Chemokine
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Drugs		Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium chloride Hydroflumethiazide Bumetanide Etacrynic acid Quinethazone Piretanide	Fostamatinib
Diseases
GWAS		Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Systemic lupus erythematosus ( 26606652)	Gut microbiota (bacterial taxa) ( 27723756) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: OXSR1 STK39 TCF12	13 interacting genes: APP BMPR1B GORASP1 OGT PAK1 RELL1 RELL2 SLC12A1 SLC12A2 SLC12A6 SMURF1 STT3B TGFBR1
Entrez ID		6557	9943
HPRD ID		02908	06809
Ensembl ID		ENSG00000074803	ENSG00000172939
Uniprot IDs		B4DPF4 Q13621 Q8IUN5	O95747
PDB IDs			2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?
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