WNK2 and ATXN1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
337

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WNK2	ATXN1
Description		WNK lysine deficient protein kinase 2	ataxin 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix Nuclear Inclusion Body
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity	DNA Binding Protein Binding Protein C-terminus Binding Poly(U) RNA Binding Poly(G) Binding Identical Protein Binding Protein Self-association
	Biological Process	Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Protein Autophosphorylation Ion Homeostasis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated RNA Processing Nervous System Development Brain Development Learning Memory Social Behavior Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development Nuclear Export
Pathways		Stimuli-sensing channels
Drugs
Diseases
GWAS		Ability to confide in someone ( 29970889) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 33381925) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Perceived sweetness of sucrose ( 31005972)	Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 30061737 29892015) Breast cancer ( 29059683) Central corneal thickness ( 32528159) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Cortical amyloid beta load ( 29860282) Fish- and plant-related diet ( 32066663) Gambling ( 22780124) General cognitive ability ( 29844566) Generalized epilepsy ( 30531953) Granulocyte count ( 27863252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Subcutaneous adipose tissue attenuation (Hounsfield unit scale) ( 27918534) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 28714469) Total body bone mineral density ( 30172743) Visceral adipose tissue attenuation (Hounslow unit scale) ( 27918534) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 29403010 32888494 27863252)
Interacting Genes		5 interacting genes: ATXN1 ESS2 MTDH WNK1 YWHAZ	293 interacting genes: - ACACA ACOT7 ADAM15 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BHLHE40 BICRAL BTG3 C10orf55 C1orf94 C7 CAMK1 CAMK2B CCDC136 CCNK CDIP1 CDK6 CDRT15P3 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F CNOT6L COIL CPSF7 CREM CRIP2 CRK CRX CRY2 CST3 CUTC DAZ2 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 EML3 ENTPD6 EPN2 ESRP1 ESRRA ETV4 EXTL3 FAM153B FAM168A FAM193B FAR1 FAT4 FDPS FHL2 FNDC9 FOSL1 FOXN4 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 H2AP H3C1 HEY2 HEYL HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSFY1 HSFY2 HSPA1A IGF2R IL34 ILVBL IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIAA2026 KIF22 KLF11 KLHL12 KLHL8 KMT2B KRTAP12-4 KRTAP13-3 LASP1 LDB1 LITAF LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 METTL27 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS1 NCAM1 NCOR1 NCOR2 NFYA NHSL2 NLGN3 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PANX2 PEPD PHPT1 PIAS1 PICALM PIM2 PITX3 PLA2G10 PLEKHB1 PLEKHN1 PML POGZ POM121 POMP PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRR20B PRR20C PRR20D PRR20E PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCC1L RCN1 REL RHOXF2 RNF31 RNF4 RPL19 SAR1A SEMA4G SETD2 SETD6 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SORCS3 SOX3 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TENT5A TENT5B TMX2 TOLLIP TOMM20 TOX4 TP53I11 TPRX1 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF1BP1L UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WASHC2C WNK1 WNK2 XPO7 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX
Entrez ID		65268	6310
HPRD ID		06951	03333
Ensembl ID		ENSG00000165238	ENSG00000124788
Uniprot IDs		F8W9F9 Q9Y3S1	P54253 Q96FF1
PDB IDs		6ELM 6FBK	1OA8 2M41 4APT 4AQP 4J2J 4J2L 6QIU
Enriched GO Terms of Interacting Partners?
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