WNK3 and TSC22D2

Number of citations of the paper that reports this interaction (PubMedID 27337956)
22

Data Source:
BioGRID (two hybrid)

		WNK3	TSC22D2
Description		WNK lysine deficient protein kinase 3	TSC22 domain family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Adherens Junction Bicellular Tight Junction
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Cell Volume Homeostasis Osmosensory Signaling Pathway Positive Regulation Of Sodium Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Blood-brain Barrier Negative Regulation Of Apoptotic Process Protein Autophosphorylation Ion Homeostasis Positive Regulation Of Calcium Ion Transport Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress
Pathways		Stimuli-sensing channels
Drugs
Diseases
GWAS		Height ( 28552196)	Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30054458 30297969) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: KLHL3 LBX1 REL TSC22D2	42 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 WNK3 ZMYM2 ZNF143 ZNF251
Entrez ID		65267	9819
HPRD ID		02289	11101
Ensembl ID		ENSG00000196632	ENSG00000196428
Uniprot IDs		Q9BYP7	B4DN36 O75157
PDB IDs		5NKP 5O1V 5O21 5O23 5O26 5O2B 5O2C
Enriched GO Terms of Interacting Partners?
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