SKP2 and MEF2D

Number of citations of the paper that reports this interaction (PubMedID 25733682)
21

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		SKP2	MEF2D
Description		S-phase kinase associated protein 2	myocyte enhancer factor 2D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination	Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Adult Heart Development Muscle Organ Development Cell Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation	Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis NGF-stimulated transcription NGF-stimulated transcription Heme signaling
Drugs
Diseases
GWAS		Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 32888494 27863252)	Body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Monocyte count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		65 interacting genes: AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CFLAR CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 EP300 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NLK ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR2A PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SLC9A3R1 SMAD4 SQSTM1 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1	24 interacting genes: - APP ASCL1 CABIN1 CARM1 CASP7 CDK6 COPS5 DNMT3L EP300 FBXO7 HDAC4 HDAC5 MAPK14 MAPK7 MEF2A MEF2C NFATC2 PRKACA PRMT5 SKP2 SNCA SP1 YWHAQ
Entrez ID		6502	4209
HPRD ID		03256	02810
Ensembl ID		ENSG00000145604	ENSG00000116604
Uniprot IDs		A0A024R069 D6R9R7 Q13309	Q14814
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST 7B5L 7B5M 7B5R
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?