HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
SKI and MECP2
Number of citations of the paper that reports this interaction (PubMedID
11441023
)
68
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vitro, in vivo)
SKI
MECP2
Description
SKI proto-oncogene
methyl-CpG binding protein 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Nuclear Body
PML Body
Transcription Repressor Complex
Protein-containing Complex
Heterochromatin
Extracellular Space
Nucleus
Nucleoplasm
Centrosome
Cytosol
Postsynapse
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
SMAD Binding
Histone Deacetylase Inhibitor Activity
DNA-binding Transcription Factor Binding
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Corepressor Activity
RNA Binding
MRNA Binding
Protein Binding
Methyl-CpG Binding
Double-stranded Methylated DNA Binding
Protein Domain Specific Binding
SiRNA Binding
Protein N-terminus Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Neural Tube Closure
Lens Morphogenesis In Camera-type Eye
Transcription, DNA-templated
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Anterior/posterior Axis Specification
Negative Regulation Of Schwann Cell Proliferation
Myotube Differentiation
Olfactory Bulb Development
Myelination In Peripheral Nervous System
Positive Regulation Of Wnt Signaling Pathway
Embryonic Limb Morphogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Histone Deacetylation
Negative Regulation Of Activin Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Camera-type Eye Development
Positive Regulation Of DNA Binding
Nose Morphogenesis
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Fibroblast Proliferation
Camera-type Eye Morphogenesis
Skeletal Muscle Fiber Development
Cell Motility
Roof Of Mouth Development
Retina Development In Camera-type Eye
Face Morphogenesis
Bone Morphogenesis
SMAD Protein Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Behavioral Fear Response
Response To Hypoxia
Startle Response
Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Regulation Of Respiratory Gaseous Exchange By Nervous System Process
Inositol Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Glutamine Metabolic Process
Cellular Biogenic Amine Metabolic Process
Mitotic Spindle Organization
Synapse Assembly
Respiratory Gaseous Exchange By Respiratory System
Long-term Memory
Protein Localization
Glucocorticoid Metabolic Process
Positive Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Visual Learning
Post-embryonic Development
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Dendrite Development
Negative Regulation Of Angiogenesis
Histone Methylation
Histone Acetylation
Proprioception
Sensory Perception Of Pain
Cerebellum Development
Ventricular System Development
Cardiolipin Metabolic Process
Social Behavior
Neuron Maturation
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Phosphatidylcholine Metabolic Process
Negative Regulation Of Smooth Muscle Cell Differentiation
Response To Other Organism
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Positive Regulation Of Microtubule Nucleation
Positive Regulation Of Histone H3-K9 Trimethylation
Positive Regulation Of DNA Methylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Pathways
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS
Alanine aminotransferase levels (
33547301
)
Body mass index (
26426971
)
Coronary artery disease (
29212778
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Myocardial infarction (
33532862
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
PR interval (
30046033
32439900
)
Systolic blood pressure (
30224653
)
Urate levels (
31578528
)
Non-albumin protein levels (
29403010
)
Red blood cell traits (
23446634
)
Schizophrenia (
24043878
)
Systemic lupus erythematosus (
26663301
26502338
19838195
)
Interacting Genes
20 interacting genes:
AKT1
GLI2
GLI3
HIPK2
JUN
MECP2
MYB
NCOR1
NFIX
PML
SIN3A
SKIL
SMAD1
SMAD2
SMAD3
SMAD4
SNW1
SPI1
TGFBR1
TRIM28
20 interacting genes:
DNMT1
DNMT3L
GTF2B
H3C15
HDAC1
HIPK2
HMGB1
LBR
NCOR1
PRKACA
PRPF40A
PRPF40B
SIN3A
SKI
SMARCA2
SMARCB1
SOX18
SPI1
TBL1X
TBL1XR1
Entrez ID
6497
4204
HPRD ID
01271
02050
Ensembl ID
ENSG00000157933
ENSG00000169057
Uniprot IDs
P12755
A0A140VKC4
D3YJ43
P51608
Q59FJ6
PDB IDs
1MR1
1SBX
5XOD
1QK9
3C2I
5BT2
6C1Y
6OGJ
6OGK
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?