SIM2 and ARNT2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		SIM2	ARNT2
Description		SIM bHLH transcription factor 2	aryl hydrocarbon receptor nuclear translocator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Nuclear Body	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Aryl Hydrocarbon Receptor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein-containing Complex Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development Embryonic Pattern Specification Cell Differentiation Lung Development	Response To Hypoxia In Utero Embryonic Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Response To Estradiol Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs
Diseases
GWAS		Asthma and hay fever ( 24388013) Cerebellum cortex volume ( 31530798) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Night sleep phenotypes ( 27126917) Red blood cell count ( 27863252)	Atrial fibrillation ( 30061737 29892015) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder ( 20351715) Body mass index ( 26426971) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		6 interacting genes: ARNT ARNT2 CRYAA MAGED1 MAST3 PRKN	71 interacting genes: ADAMTSL4 AHR AP1M1 AP3M1 APP ARNT CALCOCO2 CAPN7 CCDC33 CDR2 CEP57L1 CEP63 CTBP1 DGCR6 DTX2 DYDC1 EPAS1 FAAP20 GOLGA2 HIF1A IKZF3 KIFC3 LMO2 LMO4 LZTS2 MAGEA4 MAGED1 MEIS2 MEOX2 MIPOL1 MTDH MTUS2 NCOA3 NDE1 NPAS2 NPAS3 NPAS4 OSGIN1 PDE4DIP PLSCR1 PSMB1 RBCK1 REL RFX6 RIMBP3 RINT1 SH3GL2 SIM1 SIM2 SORBS3 SPAG5 SSBP3 SSX2IP STK16 SYCE1 TACC3 TADA2A TAX1BP3 TFIP11 TRAF1 TRAF2 TRIM23 TRIM27 TRIM37 TRIM42 TRIP6 TSPOAP1 USHBP1 USP7 VPS52 ZNF341
Entrez ID		6493	9915
HPRD ID		02935	06915
Ensembl ID		ENSG00000159263	ENSG00000172379
Uniprot IDs		Q14190	Q7Z3A3 Q86TN1 Q9HBZ2 X5DQN9
PDB IDs
Enriched GO Terms of Interacting Partners?
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