SH3BP2 and ARHGAP10

Number of citations of the paper that reports this interaction (PubMedID 25814554)
26

Data Source:
BioGRID (two hybrid)

		SH3BP2	ARHGAP10
Description		SH3 domain binding protein 2	Rho GTPase activating protein 10
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GO Annotations	Cellular Component		Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding SH3 Domain Binding	GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction	Cytoskeleton Organization Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Regulation of PAK-2p34 activity by PS-GAP/RHG10 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Hodgkin's lymphoma ( 34216518) Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)	Atrial fibrillation ( 30061737 29892015) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) QT interval ( 20031603) Resting heart rate ( 27798624) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		32 interacting genes: ABL1 ARHGAP10 CTTN DBNL ERBB2 ERBB3 ERBB4 FGFR1 FLT3 FYN GRB2 HCLS1 KIT LAT LCK MET MYO1F NSD2 PDLIM7 PLCG1 PLCG2 SH3KBP1 SH3RF1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70	10 interacting genes: ANKS1A ARF6 CDC42 HRAS PAK2 PKN1 PKN3 RHOA SH3BP2 YWHAQ
Entrez ID		6452	79658
HPRD ID		03657	07949
Ensembl ID		ENSG00000087266	ENSG00000071205
Uniprot IDs		A0A384N6E5 P78314	A0A2X0SFB3 A1A4S6
PDB IDs		2CR4 3TWR	2MIO
Enriched GO Terms of Interacting Partners?
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