ABCG5 and ABCG8

Number of citations of the paper that reports this interaction (PubMedID 12208867)
97

Data Source:
HPRD (in vivo)

		ABCG5	ABCG8
Description		ATP binding cassette subfamily G member 5	ATP binding cassette subfamily G member 8
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex
	Molecular Function	Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Cholesterol Transfer Activity ABC-type Transporter Activity	Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Cholesterol Transfer Activity ABC-type Transporter Activity
	Biological Process	Response To Nutrient Excretion Response To Xenobiotic Stimulus Response To Ionizing Radiation Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Bile Acid Signaling Pathway Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Triglyceride Homeostasis Intermembrane Lipid Transfer	Response To Nutrient Excretion Response To Xenobiotic Stimulus Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Bile Acid Signaling Pathway Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Triglyceride Homeostasis Intermembrane Lipid Transfer
Pathways		ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 19060911 20686565) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) LDL cholesterol ( 24097068 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Metabolite levels (lipoprotein measures) ( 27005778)	Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 28270201 25961943 20686565) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gallstone disease ( 30325047 30504769 30692554 27094239 17632509) LDL cholesterol ( 23726366 19060906 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Phytosterol levels ( 20529992) Refractive error ( 32231278) Total cholesterol levels ( 33339817 30275531)
Interacting Genes		1 interacting genes: ABCG8	9 interacting genes: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 MESD NR4A1 NUPR1
Entrez ID		64240	64241
HPRD ID		05678	05679
Ensembl ID		ENSG00000138075	ENSG00000143921
Uniprot IDs		Q9H222	Q9H221
PDB IDs		5DO7	5DO7
Enriched GO Terms of Interacting Partners?
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