SFRP1 and IDO1

		SFRP1	IDO1
Description		secreted frizzled related protein 1	indoleamine 2,3-dioxygenase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Collagen-containing Extracellular Matrix Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Frizzled Binding Protein Binding Heparin Binding Wnt-protein Binding Identical Protein Binding	Tryptophan 2,3-dioxygenase Activity Electron Transfer Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Ureteric Bud Development Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Proteolysis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Xenobiotic Stimulus Dorsal/ventral Axis Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Neural Crest Cell Fate Commitment Response To Organic Cyclic Compound Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Cellular Response To Fibroblast Growth Factor Stimulus Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Cellular Response To Heparin Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process	Immune System Process Tryptophan Catabolic Process Female Pregnancy Tryptophan Catabolic Process To Kynurenine Electron Transport Chain 'de Novo' NAD Biosynthetic Process From Tryptophan Regulation Of Activated T Cell Proliferation Positive Regulation Of T Cell Apoptotic Process
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Tryptophan catabolism
Drugs			Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Academic attainment (English) ( 33594131) Anti-saccade response ( 29064472) Blood protein levels ( 30072576 29875488) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Refractive astigmatism ( 30306274)	Blood metabolite levels ( 24816252) Blood protein levels ( 29875488)
Interacting Genes		10 interacting genes: FZD6 IDO1 KIAA1522 PPP1CA PPP1CC TMEM86B UBXN8 WNT1 WNT2 WNT4	11 interacting genes: ADRB3 APP DCTN6 DDX24 DUSP4 FBXL17 PPP1R16A RBPMS SFRP1 SLC20A2 TERF2IP
Entrez ID		6422	3620
HPRD ID		09165	00935
Ensembl ID		ENSG00000104332	ENSG00000131203
Uniprot IDs		Q8N474	A0A348GSI3 P14902
PDB IDs			2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PU7 6PZ1 6R63 6UBP 6V52 6WJY 7A62 7AH4 7AH5 7AH6
Enriched GO Terms of Interacting Partners?
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