SLC39A8 and ADH6

		SLC39A8	ADH6
Description		solute carrier family 39 member 8	alcohol dehydrogenase 6 (class V)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Organelle Membrane	Cytosol Extracellular Exosome
	Molecular Function	Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Anion:cation Symporter Activity Selenite:proton Symporter Activity Zinc:bicarbonate Symporter Activity	Alcohol Dehydrogenase (NAD+) Activity Alcohol Dehydrogenase Activity, Zinc-dependent NAD-retinol Dehydrogenase Activity Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein N-linked Glycosylation Arginine Metabolic Process Cobalt Ion Transport Zinc Ion Transport Cellular Cadmium Ion Homeostasis Cellular Zinc Ion Homeostasis Inorganic Anion Transport Bicarbonate Transport Cellular Manganese Ion Homeostasis Extracellular Matrix Organization Regulation Of Membrane Potential Leukocyte Adhesion To Arterial Endothelial Cell Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Iron Ion Import Across Plasma Membrane Cartilage Homeostasis Mitochondrial Manganese Ion Transmembrane Transport	Ethanol Oxidation Retinol Metabolic Process Retinoic Acid Metabolic Process Response To Ethanol
Pathways		Zinc influx into cells by the SLC39 gene family	Ethanol oxidation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701 33861876) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Allergic disease (asthma, hay fever or eczema) ( 29679657) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anterior thalamic nuclei volume ( 34006833) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Blood pressure ( 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 29381148 26961502 25673413 20935630 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878 21909115 28739976 27618452 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil percentage of white cells ( 32888494) Erythrocyte cadmium concentration in never smokers ( 27005419) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hypertension ( 31879980 21909115) Inflammatory bowel disease ( 28067908) Initial pursuit acceleration ( 29064472) Intelligence (MTAG) ( 29326435) Lateral thalamic nuclei volume ( 34006833) LDL cholesterol levels ( 32203549) Left-handedness ( 32989287) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Manganese levels ( 26025379) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Multisite chronic pain ( 33830993 31194737) NT-proBNP levels in acute coronary syndrome ( 26908625) Obese vs. thin ( 30677029) Parkinson's disease ( 32201043) Platelet distribution width ( 32888494 27863252) Problematic alcohol use ( 32451486) Red blood cell count ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656) Serum total protein level ( 29403010) Shoulder impingement or rotator cuff tear ( 33482370) Sleep duration (short sleep) ( 30846698) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 21909115 28739976 27618447 27618452 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549 32154731) Voxel-wise structural brain imaging measurements ( 30649180) vWF levels ( 30586737) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) Youthful appearance (self-reported) ( 32339537)	Alcohol dependence ( 23456092) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Aspartate aminotransferase levels ( 33547301) Esophageal cancer ( 19698717) QRS duration ( 23534349) Regular attendance at a pub or social club ( 29970889) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		6 interacting genes: ADH6 BMPR1B CXXC4 PTGER4 SMARCAD1 STPG2	9 interacting genes: ANKRD17 ARRB1 KRAS RASSF5 RPAIN RPS29 RSL1D1 SLC39A8 TNIP1
Entrez ID		64116	130
HPRD ID		12286	00067
Ensembl ID		ENSG00000138821	ENSG00000172955
Uniprot IDs		A0A024RDG0 Q9C0K1	P28332 Q8IUN7
PDB IDs
Enriched GO Terms of Interacting Partners?
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