SDHC and ARHGDIA

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		SDHC	ARHGDIA
Description		succinate dehydrogenase complex subunit C	Rho GDP dissociation inhibitor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex II, Succinate Dehydrogenase Complex (ubiquinone) Integral Component Of Membrane	Immunological Synapse Nucleus Cytosol Cytoskeleton Membrane Synapse Extracellular Exosome
	Molecular Function	Succinate Dehydrogenase Activity Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Fatty Acid Binding Protein Binding Protein Kinase Binding Small GTPase Binding Hsp90 Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration	Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Cell Shape Negative Regulation Of Cell Migration Regulation Of Protein Localization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Redox State Semaphorin-plexin Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle)	Axonal growth inhibition (RHOA activation) Axonal growth stimulation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		5 interacting genes: ARHGDIA DEDD MDM2 RGS4 XRCC6	41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		6391	396
HPRD ID		03878	03565
Ensembl ID		ENSG00000143252	ENSG00000141522
Uniprot IDs		A0A0S2Z4B7 A0A0S2Z4C9 Q99643	J3QQX2 P52565 V9HWE8
PDB IDs			1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80
Enriched GO Terms of Interacting Partners?
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