CXCL6 and PPBP

Number of citations of the paper that reports this interaction (PubMedID 28381538)
37

Data Source:
BioGRID (pull down)

		CXCL6	PPBP
Description		C-X-C motif chemokine ligand 6	pro-platelet basic protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen
	Molecular Function	Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Leukocyte Homeostasis Chemotaxis Inflammatory Response Signal Transduction Cell-cell Signaling Neutrophil Chemotaxis Regulation Of Chemokine Production Neutrophil Activation Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Cellular Response To Lipopolysaccharide	Inflammatory Response Neutrophil Chemotaxis Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs			Ethanesulfonic acid Copper
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494) Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Metabolite levels ( 22916037)
Interacting Genes		14 interacting genes: CCL11 CCL5 CCL7 CCL8 CXCL1 CXCL10 CXCL12 CXCL2 CXCL3 CXCR1 CXCR2 MMP9 PF4 PPBP	32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID		6372	5473
HPRD ID		00735	07171
Ensembl ID		ENSG00000124875	ENSG00000163736
Uniprot IDs		P80162	P02775
PDB IDs			1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?
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