CCL20 and VCAN

Number of citations of the paper that reports this interaction (PubMedID 11083865)
65

Data Source:
HPRD (in vitro)

		CCL20	VCAN
Description		C-C motif chemokine ligand 20	versican
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Chemokine Activity CCR6 Chemokine Receptor Binding CCR Chemokine Receptor Binding	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Neutrophil Chemotaxis Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Bacterium Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor T Cell Migration Thymocyte Migration Positive Regulation Of T Cell Migration	Skeletal System Development Osteoblast Differentiation Cell Adhesion Multicellular Organism Development Central Nervous System Development Cell Recognition
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation
Drugs			Hyaluronic acid
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31959851 30929738 34103634 32296059) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood pressure ( 17903302) Crohn's disease ( 26192919) Eating disorders (purging via substances) ( 23568457) Inflammatory bowel disease ( 26192919) Primary biliary cholangitis ( 26394269) Ulcerative colitis ( 26192919)	Appendicular lean mass ( 28724990) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness (mean) ( 31801372) Cortical surface area (MOSTest) ( 32665545) Cortical volume ( 32963231) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Joint mobility (Beighton score) ( 27182965) Laryngeal squamous cell carcinoma ( 25194280) Lean body mass ( 28724990) Major depressive disorder ( 20516156) Optic disc size ( 31809533) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter hyperintensity volume ( 29752348 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter integrity (fractional anisotropy) ( 29752348 32358547) White matter integrity (mean diffusivity) ( 29752348 32358547)
Interacting Genes		11 interacting genes: CCL5 CCR6 CXCL11 CXCL12 CXCL17 CXCL5 MTDH PF4 TGFB3 VCAN XCL2	24 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A PTPRF RAB19 SELL SELP SELPLG TNR XCL1
Entrez ID		6364	1462
HPRD ID		03571	00340
Ensembl ID		ENSG00000115009	ENSG00000038427
Uniprot IDs		P78556	A0A024RAL1 A0A024RAP3 A0A024RAQ9 P13611 Q59FG9 Q6MZK8 Q86W61
PDB IDs		1M8A 2HCI 2JYO 5UR7 6WWZ
Enriched GO Terms of Interacting Partners?
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