ATXN2 and PLS3

Number of citations of the paper that reports this interaction (PubMedID 16115810)
40

Data Source:
HPRD (two hybrid, in vivo)

		ATXN2	PLS3
Description		ataxin 2	plastin 3
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Polysome Cytoplasmic Stress Granule Membrane Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex	Cytoplasm Cytosol Actin Filament Plasma Membrane Actin Filament Bundle
	Molecular Function	RNA Binding Epidermal Growth Factor Receptor Binding Protein Binding Protein C-terminus Binding	Calcium Ion Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Receptor Internalization Regulation Of Translation RNA Metabolic Process P-body Assembly Stress Granule Assembly RNA Transport	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development
Pathways
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Alopecia areata ( 25608926) Apolipoprotein B levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 30929738 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Beta-2 microglubulin plasma levels ( 23417110) Blood osmolality (transformed sodium) ( 28360221) Blood pressure ( 21909110) Body mass index ( 26426971) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Caffeine consumption from coffee or tea ( 33287642) Celiac disease ( 22057235 18311140) Chronic kidney disease ( 20383146) Coronary artery disease ( 29212778 30104761) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 27736895 19430483) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Gastroesophageal reflux disease ( 31527586) Glaucoma (primary open-angle) ( 26752265 33627673) Glomerular filtration rate (cystatin C) ( 28452372) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) Heart failure ( 31919418) Hematocrit ( 19862010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 30054594) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricle diastolic internal dimension ( 28394258) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 30226566 33532862) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 24026423 29403010 33545615 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Reaction time ( 29844566) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Reticulocyte fraction of red cells ( 27863252) Retinal vascular caliber ( 21060863) Sarcoidosis ( 26051272) Serum alkaline phosphatase levels ( 33547301) Serum total protein level ( 29403010) SjÃ¶gren's syndrome ( 24097067) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962 26502338 28714469) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Total cholesterol levels ( 30275531) Urate levels ( 31578528 23263486) Vitiligo ( 27723757) White blood cell count ( 32888494)	Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)
Interacting Genes		23 interacting genes: ACTN1 ACTN2 ATXN1 BAG6 BIN1 CHGB GFI1B GOLGA6L5P IDH3B IMPDH2 KIFBP LCP1 MIR128-1 MIR34B MIR7-1 NCOA4 PABPC1 PLS3 POLR1H RBFOX1 SH3GL2 SH3GL3 TDRD7	17 interacting genes: ACRV1 APP ASGR1 ATXN2 CUL4B CXCR5 FRYL LRCH2 NRSN1 OGT PTPN5 TGIF2 TRPC5 TSPAN32 WFDC2 ZBTB33 ZNF195
Entrez ID		6311	5358
HPRD ID		03307	02133
Ensembl ID		ENSG00000204842	ENSG00000102024
Uniprot IDs		F8VQP2 Q2M2R5 Q99700	B4DPW9 P13797
PDB IDs		3KTR	1AOA 1WJO
Enriched GO Terms of Interacting Partners?
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