RYR2 and SMAD5

  • Number of citations of the paper that reports this interaction (PubMedID 15231748)
  • 99

RYR2

SMAD5

Description ryanodine receptor 2 SMAD family member 5
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acute lymphoblastic leukemia (childhood) ( 19684603)
  • Bipolar disorder and eating disorder ( 26433762)
  • Cerivastatin-induced rhabdomyolysis ( 21386754)
  • cognitive impairment (MMSE score) in Parkinson’s disease ( 33613413)
  • Exercise treadmill test traits ( 17903301)
  • General risk tolerance (MTAG) ( 30643258)
  • Hippocampal volume ( 31530798)
  • Hypertension ( 17554300)
  • Lipid traits ( 30576415 24386095)
  • Lung function (FEV1) ( 30061609)
  • Lung function (FVC) ( 30061609)
  • Metabolite levels ( 23823483)
  • Obesity-related traits ( 23251661)
  • Postoperative stroke after cardiac surgery ( 30678657)
  • PR interval ( 32439900)
  • Response to taxane treatment (docetaxel) ( 23006423)
  • Smoking initiation (ever regular vs never regular) ( 30679032)
  • Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566)
  • Insomnia symptoms (never/rarely vs. usually) ( 30804566)
  • Mean platelet volume ( 32888494)
  • Sleep duration (short sleep) ( 30846698)
Interacting Genes 16 interacting genes: AKAP6 ALB CACNA1C FKBP1B HOMER1 HSPB2 ITPR1 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI 46 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8
Entrez ID 6262 4090
HPRD ID 01619 04381
Ensembl ID ENSG00000198626 ENSG00000113658
Uniprot IDs Q92736 Q68DB7 Q99717
PDB IDs 4JKQ 6Y4O 6Y4P 6FZS 6TCE
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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