RYR1 and TRDN

Number of citations of the paper that reports this interaction (PubMedID 9287354)
150

Data Source:
HPRD (in vitro, in vivo)

		RYR1	TRDN
Description		ryanodine receptor 1	triadin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Integral Component Of Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex	Endoplasmic Reticulum Cytosol Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen
	Molecular Function	Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Calmodulin Binding ATP Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Calcium Ion Cellular Response To Caffeine	Cellular Calcium Ion Homeostasis Muscle Contraction Response To Bacterium Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Microtubule Organization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Heart Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Membrane Potential Endoplasmic Reticulum Membrane Organization Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Stimuli-sensing channels Ion homeostasis	Stimuli-sensing channels Ion homeostasis
Drugs		Caffeine Dantrolene Suramin Tetracaine
Diseases
GWAS		Abstraction and mental flexibility ( 31596458) Appendicular lean mass ( 33097823) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Borderline personality disorder ( 28632202) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Intraocular pressure ( 30591961) Metabolite levels ( 23823483) Nickel levels ( 26025379) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		19 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3	10 interacting genes: ASPH CALM1 CASQ1 CASQ2 HRC KCNE4 PPIB PTPRN RYR1 SOCS3
Entrez ID		6261	10345
HPRD ID		01618	04474
Ensembl ID		ENSG00000196218	ENSG00000186439
Uniprot IDs		P21817	A0A590UJV0 H9ME53 Q13061 Q8IVK2
PDB IDs		6UHI 6UHS
Enriched GO Terms of Interacting Partners?
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