RPS6KB2 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
8

Data Source:
BioGRID (enzymatic study)

		RPS6KB2	FBXO25
Description		ribosomal protein S6 kinase B2	F-box protein 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity ATP Binding Peptide Binding Protein Serine Kinase Activity	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Translation Signal Transduction Peptidyl-serine Phosphorylation TOR Signaling Protein Kinase B Signaling Positive Regulation Of Translational Initiation	Protein Ubiquitination
Pathways		AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		22 interacting genes: BTK COASY CSNK2B EEF2K EP300 FBXO25 FYN HNRNPA1 IKBKG KAT2B LRRK2 LYN MAPK8IP2 MTOR NEDD4L PDGFRB PDPK1 PRKCE RPS6 SRC SRPK1 SYK	83 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DAXX DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		6199	26260
HPRD ID		10203	16439
Ensembl ID		ENSG00000175634	ENSG00000147364
Uniprot IDs		Q9UBS0	A0A024QZ88 Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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