BCS1L and ORC2

		BCS1L	ORC2
Description		BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	origin recognition complex subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	Protein Binding ATP Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	Mitochondrion Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Cytochrome C Oxidase Assembly Mitochondrial Respiratory Chain Complex III Assembly	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Initiation
Pathways		Mitochondrial protein import	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)	Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		14 interacting genes: AOX1 ARHGAP18 CD28 CLK1 CTLA4 DDX24 DNAJA1 MRPS12 MTDH ORC2 RP9 RPE SLC29A1 WDFY1	31 interacting genes: BCS1L CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RFWD3 RIPPLY3 RPA1 RPA2 SHANK2 XRCC5
Entrez ID		617	4999
HPRD ID		04708	03112
Ensembl ID		ENSG00000074582	ENSG00000115942
Uniprot IDs		A0A024R445 A8JZZ8 Q9Y276	A0A024R411 Q13416
PDB IDs			5C8H 5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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