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RPL11 and STAT3
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
87
Data Source:
BioGRID
(two hybrid)
RPL11
STAT3
Description
ribosomal protein L11
signal transducer and activator of transcription 3
Image
GO Annotations
Cellular Component
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Membrane
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Protein-containing Complex
Polysomal Ribosome
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrial Inner Membrane
Cytosol
Plasma Membrane
Postsynaptic Density
RNA Polymerase II Transcription Regulator Complex
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Molecular Function
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
5S RRNA Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Inhibitor Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Chromatin DNA Binding
CCR5 Chemokine Receptor Binding
Glucocorticoid Receptor Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Primary MiRNA Binding
Biological Process
Ribosomal Large Subunit Assembly
Cytoplasmic Translation
RRNA Processing
Translation
Protein Targeting
Positive Regulation Of Gene Expression
Positive Regulation Of Protein Binding
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Ribosomal Large Subunit Biogenesis
Protein Stabilization
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Ubiquitin Protein Ligase Activity
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Neddylation
Negative Regulation Of Transcription By RNA Polymerase II
Temperature Homeostasis
Eye Photoreceptor Cell Differentiation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Defense Response
Acute-phase Response
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Receptor Signaling Pathway Via JAK-STAT
Nervous System Development
Aging
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Negative Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Phosphorylation
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Sexual Reproduction
Positive Regulation Of Cell Migration
Intracellular Receptor Signaling Pathway
Response To Estradiol
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Hormone Stimulus
Leptin-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Regulation Of Cell Population Proliferation
Glucose Homeostasis
Eating Behavior
MRNA Transcription By RNA Polymerase II
Response To Peptide Hormone
Cellular Response To Leptin Stimulus
Response To Leptin
Response To Ethanol
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Angiogenesis
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Mitochondrial Membrane Permeability
Astrocyte Differentiation
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Cycle
Radial Glial Cell Differentiation
Regulation Of Feeding Behavior
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
Cellular Response To Organic Cyclic Compound
T-helper 17 Type Immune Response
T-helper 17 Cell Lineage Commitment
Energy Homeostasis
Postsynapse To Nucleus Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neuron Death
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Primary MiRNA Processing
Positive Regulation Of Gene Silencing By MiRNA
Negative Regulation Of Stem Cell Differentiation
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Neuron Migration
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Interleukin-6 signaling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signalling to STAT3
Signaling by ALK
Senescence-Associated Secretory Phenotype (SASP)
Signaling by Leptin
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Association of TriC/CCT with target proteins during biosynthesis
Transcriptional regulation of pluripotent stem cells
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Transcriptional regulation of granulopoiesis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF3 (G-CSF)
STAT3 nuclear events downstream of ALK signaling
Inactivation of CSF3 (G-CSF) signaling
Cytoprotection by HMOX1
Signaling by ALK fusions and activated point mutants
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Drugs
(S)-3-phenyllactic acid
Anisomycin
Puromycin
ENMD-1198
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Atopic dermatitis (
26482879
)
Autoimmune thyroid disease (
32581359
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Composite immunoglobulin trait (IgA/IgG) (
28628107
)
Crohn's disease (
18587394
28067908
21102463
23266558
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
30578418
)
Inflammatory bowel disease (
27569725
28067908
26278503
23128233
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
22190364
24076602
21833088
20159113
)
Myocardial infarction (
33532862
)
Psoriasis (
25903422
23143594
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
30054458
)
Ulcerative colitis (
28067908
)
Interacting Genes
26 interacting genes:
APP
ARFGAP1
BLMH
CAMK2B
CDKN2A
DVL3
GRWD1
HP
HSPB2
IGF1R
IP6K1
KRT40
KRTAP10-7
LIG4
MDM2
OGT
OSBPL3
PAIP2
PCAT1
PML
SDHB
SENP1
STAT3
TIGAR
TP73
UBE2I
211 interacting genes:
ABL2
ADRB2
AMBP
AR
ARFIP2
ASXL1
ATF3
BATF3
BCKDK
BHLHE40
BICD1
BLK
BMX
BRCA1
BRWD1
CA8
CAPN1
CAPNS1
CBL
CCDC87
CCND1
CCR1
CCR5
CDK9
CDKN1A
CEP120
CHTF18
CNDP2
CORO1A
CREBBP
CSF2RB
CSF3R
CXCR4
DAXX
DOK2
DOK3
DTNA
ECH1
EGFR
EIF2AK2
ELP2
EP300
EPHA3
ERBB2
ERBIN
ESR1
FAM117B
FBXW7
FER
FES
FGFR3
FGFR4
FGR
FHL2
FLT1
FOXM1
FYN
GAS5
GATA1
GATA2
GHR
GNL3
GSTCD
GTF2I
HCK
HDAC1
HDAC2
HDAC3
HES1
HES5
HESX1
HIF1A
HIVEP1
HLA-A
HNF1A
HNRNPM
HOXC11
HSP90AA1
HSP90AB1
IFNAR1
IFNAR2
IGF1R
IL1RAP
IL22RA1
IL23R
IL2RA
IL2RB
IL6R
IL6ST
IL7R
IMPDH2
IRAK1
JAK1
JAK2
JAK3
JUN
KAT5
KDM1A
KHDRBS1
KLF15
KPNA1
KPNA6
KRTAP10-7
LAMB2
LASP1
LCK
LEPR
LMO2
LYN
MAP3K13
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MEG3
MET
MNDA
MORC4
MPZL1
MRPS31
MTOR
MYOD1
NACAD
NCOA1
NDUFA13
NFE2L2
NFKB1
NFKBIZ
NIF3L1
NLK
NMI
NR3C1
NR4A1
NUFIP2
NXT2
OFCC1
OGDHL
PAFAH1B2
PAQR7
PCBD2
PDGFRA
PDGFRB
PDIA3
PELP1
PIAS3
PIK3R1
PIK3R2
PIK3R3
PINK1
PML
POM121
PPARD
PRKCD
PTK2B
PTMA
PTPN1
PTPN11
PTPN2
RABGAP1
RAC1
RACK1
RB1
RELA
RET
RPA2
RPL11
RPS6KA5
RPS9
RRAD
SCAF11
SETD7
SH2D2A
SH3BP2
SIAH2
SIN3A
SMARCA4
SPRY1
SRC
SRI
SRRT
SS18L1
STAP2
STAT1
STAT4
STAT5A
STAT5B
STAT6
STMN1
SULT2A1
SUMO4
SUPT20H
SYK
TAB3
TASOR2
TDG
TM4SF19
TRIM28
TRIP10
TSHR
TSLP
TWIST1
VPS39
WDFY3
ZFPM2
ZNF148
ZNF281
ZNF467
ZNF557
ZNF829
ZNRD2
Entrez ID
6135
6774
HPRD ID
10364
00026
Ensembl ID
ENSG00000142676
ENSG00000168610
Uniprot IDs
P62913
Q5VVD0
A0A7I2V395
P40763
PDB IDs
4UG0
4V6X
4XXB
5AJ0
5LKS
5T2C
6EK0
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
7BHP
5AX3
5U5S
6NJS
6NUQ
6QHD
6TLC
Enriched GO Terms of Interacting Partners
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