RLF and RIT2

Number of citations of the paper that reports this interaction (PubMedID 10545207)
27

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RLF	RIT2
Description		RLF zinc finger	Ras like without CAAX 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Plasma Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding	Chromatin Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding Semaphorin Receptor Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Monomethylation	MAPK Cascade Regulation Of Protein Phosphorylation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling
Pathways			Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 30498476) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30679032) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 26426971 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 22451204 25064009 32201043 27182965 21738487 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		8 interacting genes: CLK1 FBXL17 GCH1 PPT1 PRPF40A RIT1 RIT2 TRIM14	13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2
Entrez ID		6018	6014
HPRD ID		01614	15253
Ensembl ID		ENSG00000117000	ENSG00000152214
Uniprot IDs		Q13129	Q99578
PDB IDs
Enriched GO Terms of Interacting Partners?
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