GRK1 and RHO

Number of citations of the paper that reports this interaction (PubMedID 11498053)
58

Data Source:
HPRD (in vitro, in vivo)

		GRK1	RHO
Description		G protein-coupled receptor kinase 1	rhodopsin
Image
GO Annotations	Cellular Component	Cytoplasm Photoreceptor Disc Membrane	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Integral Component Of Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Sperm Head Plasma Membrane
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Protein Autophosphorylation	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Absorption Of Visible Light Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Thermotaxis Photoreceptor Cell Maintenance Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade	The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs			Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Dexfosfoserine
Diseases
GWAS			Diisocyanate-induced asthma ( 25918132) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: ADRB2 CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG	12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG
Entrez ID		6011	6010
HPRD ID		01585	01584
Ensembl ID		ENSG00000185974	ENSG00000163914
Uniprot IDs		Q15835	P08100
PDB IDs		5AFP	4ZWJ 5DGY 5W0P 6CMO
Enriched GO Terms of Interacting Partners?
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