RGS7 and SDCCAG8

		RGS7	SDCCAG8
Description		regulator of G protein signaling 7	SHH signaling and ciliogenesis regulator SDCCAG8
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Centrosome Centriole Cytosol Cell-cell Junction Centriolar Satellite Ciliary Basal Body Photoreceptor Cell Cilium
	Molecular Function	GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity	Neuron Migration Centrosome Cycle Establishment Of Cell Polarity Cell Projection Organization Microtubule Organizing Center Organization Tube Formation Regulation Of Cilium Assembly
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure ( 29208002) Ischemic stroke (cardioembolic) ( 29531354) Longevity (90 years and older) ( 25199915) Major depressive disorder ( 27479909) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Western dietary pattern ( 28644415)	Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 29124443) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 28135244 27841878 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Mean platelet volume ( 32888494) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Obesity (early onset extreme) ( 20421936) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656 30285260 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Toenail selenium levels ( 25343990) Walking pace ( 33128006)
Interacting Genes		17 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SDCCAG8 SNAPIN YWHAB YWHAQ	5 interacting genes: AKT3 CEP170 FBXO7 RGS7 TNS2
Entrez ID		6000	10806
HPRD ID		03948	10215
Ensembl ID		ENSG00000182901	ENSG00000054282
Uniprot IDs		B7Z223 B7Z257 P49802	Q86SQ7
PDB IDs		2A72 2D9J
Enriched GO Terms of Interacting Partners?
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