TRPV4 and YES1

Number of citations of the paper that reports this interaction (PubMedID 12538589)
47

Data Source:
HPRD (in vivo, in vitro)

		TRPV4	YES1
Description		transient receptor potential cation channel subfamily V member 4	YES proto-oncogene 1, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane	Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Actin Binding Osmosensor Activity Protein Kinase C Binding Ion Channel Activity Cation Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Microtubule Binding Lipid Binding Stretch-activated, Cation-selective, Calcium Channel Activity Protein Kinase Binding SH2 Domain Binding Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding Actin Filament Binding	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Transmembrane Transporter Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Diet Induced Thermogenesis Calcium Ion Transport Cellular Calcium Ion Homeostasis Cell Volume Homeostasis Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Neuron Projection Development Vasopressin Secretion Positive Regulation Of Microtubule Depolymerization Actin Cytoskeleton Reorganization Positive Regulation Of Interleukin-6 Production Response To Insulin Cellular Response To Heat Hyperosmotic Salinity Response Glucose Homeostasis Positive Regulation Of Vascular Permeability Cortical Microtubule Organization Positive Regulation Of Striated Muscle Contraction Positive Regulation Of JNK Cascade Microtubule Polymerization Regulation Of Response To Osmotic Stress Positive Regulation Of Inflammatory Response Multicellular Organismal Water Homeostasis Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response Cellular Hypotonic Salinity Response Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Energy Homeostasis Blood Vessel Endothelial Cell Delamination Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Negative Regulation Of Brown Fat Cell Differentiation Regulation Of Aerobic Respiration Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Glucose Transmembrane Transport Peptidyl-tyrosine Phosphorylation Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		TRP channels	Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Drugs		Cannabidiol Butamben Medical Cannabis Nabiximols	Dasatinib Fostamatinib
Diseases
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 30224653 29403010 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)
Interacting Genes		14 interacting genes: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1	100 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GAS8 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE PXN RASA1 RPL10 SH3GLB2 SKAP2 SLC9A3R1 SOCS1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYMS TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B
Entrez ID		59341	7525
HPRD ID		05667	01285
Ensembl ID		ENSG00000111199	ENSG00000176105
Uniprot IDs		Q9HBA0	P07947
PDB IDs		4DX1 4DX2	2HDA
Enriched GO Terms of Interacting Partners?
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