TLNRD1 and SH2B2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TLNRD1	SH2B2
Description		talin rod domain containing 1	SH2B adaptor protein 2
Image
GO Annotations	Cellular Component	Stress Fiber	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding
	Biological Process		B-1 B Cell Homeostasis Nervous System Development Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Ras Protein Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation
Pathways			Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)	Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)
Interacting Genes		4 interacting genes: CCM2 LRP6 PICK1 SH2B2	43 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JADE2 JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417
Entrez ID		59274	10603
HPRD ID		11300	16097
Ensembl ID		ENSG00000140406
Uniprot IDs		Q9H1K6	O14492
PDB IDs		6XZ3 6XZ4	1Q2H
Enriched GO Terms of Interacting Partners?
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