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RB1 and LIN54
Number of citations of the paper that reports this interaction (PubMedID
15479636
)
150
Data Source:
BioGRID
(pull down)
RB1
LIN54
Description
RB transcriptional corepressor 1
lin-54 DREAM MuvB core complex component
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Spindle
Cytosol
SWI/SNF Complex
PML Body
Rb-E2F Complex
Nucleus
Nucleoplasm
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Transcription Regulatory Region Nucleic Acid Binding
Minor Groove Of Adenine-thymine-rich DNA Binding
Protein Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Tissue Homeostasis
Aortic Valve Morphogenesis
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Cell Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Cell Division
Neuron Apoptotic Process
Regulation Of Cell Cycle
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Cohesin Loading
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Tau-protein Kinase Activity
Positive Regulation Of Extracellular Matrix Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Transcription, DNA-templated
Cell Cycle
Nucleosome Positioning
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin A:Cdk2-associated events at S phase entry
Drugs
Insulin human
Insulin pork
Diseases
GWAS
Birth weight (
31043758
27680694
)
Chronic kidney disease (
26420894
)
Diastolic blood pressure (
34074324
)
Lymphocyte counts (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Hematocrit (
32888494
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Platelet distribution width (
32888494
)
Pulse pressure (
30224653
30578418
)
Red blood cell count (
29403010
32888494
27863252
)
Red cell distribution width (
32888494
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Interacting Genes
199 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX1
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDADC1
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CNTN3
CORO2A
COX17
CREG1
CRYBA4
CSK
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
ESD
FANCC
FBP1
FBP2
FOS
FRK
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
LRCH1
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MTRF1
MYC
MYOD1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PCDHB5
PELP1
PHB
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TP53
TRAP1
TRIM27
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
7 interacting genes:
BANP
NFYC
RB1
SF3A2
SP3
ZNF143
ZNF76
Entrez ID
5925
132660
HPRD ID
01574
13218
Ensembl ID
ENSG00000139687
ENSG00000189308
Uniprot IDs
A0A024RDV3
P06400
Q6MZP7
Q7Z3G2
PDB IDs
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
5FD3
Enriched GO Terms of Interacting Partners
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