RAG1 and RAG2

Number of citations of the paper that reports this interaction (PubMedID 9036966)
16

Data Source:
HPRD (in vivo, in vitro)

		RAG1	RAG2
Description		recombination activating 1	recombination activating 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	Nucleoplasm DNA Recombinase Complex
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity	Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Methylated Histone Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Sequence-specific DNA Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response	B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment Chromatin Organization Protein Ubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination Defense Response To Bacterium Positive Regulation Of Organ Growth
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 24390342)	Rheumatoid arthritis ( 24390342)
Interacting Genes		22 interacting genes: APOF APP CAPRIN1 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 PAX6 RAG2 SNX6 TBCA UBC UBE2C UBE2D1 UBE2D2 UBE2H	6 interacting genes: CAPRIN1 IPO5 LMO2 RAG1 RCN1 SKP2
Entrez ID		5896	5897
HPRD ID		01556	08913
Ensembl ID		ENSG00000166349	ENSG00000175097
Uniprot IDs		P15918	P55895
PDB IDs
Enriched GO Terms of Interacting Partners?
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