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RAD23B and PSMD4
Number of citations of the paper that reports this interaction (PubMedID
17662948
)
87
Data Source:
HPRD
(in vivo)
RAD23B
PSMD4
Description
RAD23 homolog B, nucleotide excision repair protein
proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
XPC Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Accessory Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Binding
Proteasome Binding
RNA Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Biological Process
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair
Spermatogenesis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Embryonic Organ Development
Cellular Response To Interleukin-7
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Josephin domain DUBs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Body mass index (
20966902
)
Brain morphology (MOSTest) (
32665545
)
Breast cancer (
21263130
)
Chronotype (
30696823
)
Cutaneous malignant melanoma (
26237428
)
Melanoma (
28212542
)
Prostate cancer (
23023329
)
Body mass index (
26426971
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
30 interacting genes:
ADRM1
ATXN3
CALM1
DBI
DEAF1
HIP1
HMGB1
MKRN1
MLH1
MPG
NGLY1
OGT
PAQR3
PAX3
PNMA5
POU6F2
PSMC2
PSMD4
PUF60
RPA1
RSC1A1
TAX1BP1
TDG
UBA2
UBB
UBC
UBE3A
USP25
XPC
ZFAND5
46 interacting genes:
ADRM1
APP
BTRC
CCNA2
CUL1
EGFR
FBXO25
FLOT1
GNB5
H2AC4
H2BC3
ID1
MAP3K1
MDM2
MYOD1
NEDD4
NEDD4L
NEDD8
NUB1
OGT
PRKN
PSMC3
PSMD7
PTEN
RAD23A
RAD23B
RASSF8
RBCK1
SCHIP1
SIAH2
SMURF1
SREBF2
STUB1
TCF3
TCP11L1
TMEM129
TP53
TRIM63
UBB
UBC
UBD
UBE2C
UBQLN1
UBQLN2
USP7
XPC
Entrez ID
5887
5710
HPRD ID
06772
03386
Ensembl ID
ENSG00000119318
ENSG00000159352
Uniprot IDs
B7Z4W4
P54727
P55036
Q5VWC4
PDB IDs
1P1A
1PVE
1UEL
1P9C
1P9D
1UEL
1YX4
1YX5
1YX6
2KDE
2KDF
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6MUN
6U19
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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