PTBP2 and ELAVL1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
163

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		PTBP2	ELAVL1
Description		polypyrimidine tract binding protein 2	ELAV like RNA binding protein 1
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GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA Binding	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity
	Biological Process	MRNA Processing RNA Splicing Negative Regulation Of RNA Splicing Regulation Of RNA Splicing	Protein Import Into Nucleus Posttranscriptional Gene Silencing Positive Regulation Of Translation MRNA Stabilization Protein Homooligomerization Negative Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways			HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Daytime nap ( 33568662) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 19571811 22688191) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398 30944420) Waist circumference ( 25673412)	Blood protein levels ( 28240269)
Interacting Genes		22 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GBP1 GOLGA2 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 OGT PCBP3 PKN2 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA TOM1	39 interacting genes: ANP32A ANP32B APOE C12orf75 CARM1 CELF2 CHEK2 CTNNB1 DNM2 ERG FAF2 GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA
Entrez ID		58155	1994
HPRD ID		12233	16025
Ensembl ID		ENSG00000117569	ENSG00000066044
Uniprot IDs		A0A6Q8PFE6 A0A7I2RVZ4 B4DSS8 B4DSU5 Q9UKA9	Q15717
PDB IDs		2CQ1 2MJU 4CQ1	3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?
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