ACTA1 and USP6NL

Number of citations of the paper that reports this interaction (PubMedID 15152255)
111

Data Source:
HPRD (in vitro)

		ACTA1	USP6NL
Description		actin alpha 1, skeletal muscle	USP6 N-terminal like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Dynactin Complex Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Cytosol Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	GTPase Activator Activity Small GTPase Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration	Intracellular Protein Transport Golgi Organization Virion Assembly Retrograde Transport, Plasma Membrane To Golgi Positive Regulation Of GTPase Activity Plasma Membrane To Endosome Transport Activation Of GTPase Activity Regulation Of Cilium Assembly Regulation Of Golgi Organization
Pathways		Striated Muscle Contraction	Retrograde transport at the Trans-Golgi-Network
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases
GWAS			Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) LDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Obesity-related traits ( 23251661)
Interacting Genes		114 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	6 interacting genes: ACTA1 ACTN4 APP EPS8 GRB2 RAB5A
Entrez ID		58	9712
HPRD ID		00030	08957
Ensembl ID		ENSG00000143632	ENSG00000148429
Uniprot IDs		P68133	Q92738 X6RAB3
PDB IDs
Enriched GO Terms of Interacting Partners?
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