GRAMD1A and TLR7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GRAMD1A	TLR7
Description		GRAM domain containing 1A	toll like receptor 7
Image		No pdb structure
GO Annotations	Cellular Component	Autophagosome Cytosol Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Organelle Membrane Contact Site Endoplasmic Reticulum-plasma Membrane Contact Site	Golgi Membrane Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Phagosome Endolysosome Membrane Receptor Complex
	Molecular Function	Protein Binding Cholesterol Binding Cholesterol Transfer Activity	Double-stranded RNA Binding Single-stranded RNA Binding NAD+ Nucleosidase Activity Transmembrane Signaling Receptor Activity Protein Binding SiRNA Binding Pattern Recognition Receptor Activity
	Biological Process	Autophagy Sterol Transport Cellular Response To Cholesterol Intermembrane Lipid Transfer	Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 7 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Defense Response To Virus Cellular Response To Mechanical Stimulus Cellular Response To Virus Positive Regulation Of NIK/NF-kappaB Signaling
Pathways			Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs			Imiquimod Hydroxychloroquine Isatoribine ANA971 Golotimod Resiquimod
Diseases
GWAS		Cognitive decline (age-related) ( 28078323) Hippocampal volume in Alzheimer's disease dementia ( 29274321)	Celiac disease ( 20190752)
Interacting Genes		4 interacting genes: CCR1 GMCL1 MAL TLR7	2 interacting genes: GRAMD1A MYD88
Entrez ID		57655	51284
HPRD ID		11153	02295
Ensembl ID		ENSG00000089351	ENSG00000196664
Uniprot IDs		B3KQF7 B3KUH3 M0QZ12 Q96CP6	B2R9N9 Q9NYK1
PDB IDs			7CYN
Enriched GO Terms of Interacting Partners?
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